By Arthur Henderson, RN, BA, CNOR, CRCST, CHL, ASQ-CQIA, GTS
In the world of sterile processing, active ingredients tend to be the focus. Often, this leads to a belief that all products with the same active ingredient perform the same. Nothing can be further from the truth. Nothing illustrates this more than pain killer medications, such as acetaminophen. Acetaminophen can include ingredients to make it a solid pill, a gel pill, or a liquid. Some ingredients cause the acetaminophen to be slowly released extending the time that it controls pain. Other ingredients help reduce the possibility of upset stomach from ingesting the medication. Though the active ingredient is the same in all these medications, the formulation significantly affects how the medication will work. Imagine if an individual with a sensitive stomach got a normal pill or a patient recovering from a procedure did not get the extended-release version.
Many sterile processing (SP) professionals assume that products using peracetic acid are all the same. Of greater concern is that this belief can lead to improper selection and use. Understanding how formulations work can help in proper selection and reinforce the need to follow the product’s instructions for use.
Learning Objectives
- Explain the effect that composition has on chemistry performance
- Describe the impact of inactive ingredients on oxidative chemistry performance
About the Author

Arthur Henderson, RN, BA, CNOR, CRCST, CHL, CQIA, GTS, is a senior clinical education specialist for STERIS Corporation. His areas of responsibility include education, clinical support, and troubleshooting issues related to sterilization, high-level disinfection, and infection control. Prior to STERIS, Arthur gained extensive perioperative management experience in acute care hospitals in both the OR and sterile processing departments. He has more than twenty-five years of experience as a registered nurse and has worked in a variety of specialties, including GI, open heart, neurosurgery, and cardiothoracic intensive care.
Critical Connections: Improving SP and OR Synergy
Sterilization Quality Control: Your Path to Protecting Your Patients
Ensuring Success: Become a Preceptor for Robotic Assisted Surgery Instruments in the Sterile Processing Department
Lost in Translation: Ethical Dilemmas in Medical Manufacturing Instructions
What Sterile Processing Should Know About Multidrug-Resistant Organisms (MDRO)
Making the Right Choice for Sterile Processing Consumable Stock Outages
UV-C Disinfection Technologies: How it works and what are the current applications for health care settings
The Differences Between Peracetic Acid High-level Disinfectants and Sterilants
The Mystery of Bowie & Dick: Alterations in the Vacuum on Your Sterilizer Throughout the Year
Meeting the Challenges of Endoscope Reprocessing and Documentation
Education Nation: Sterile Processing Quality Management Systems
Product testing: The overlooked 4th pillar of a robust sterilization process monitoring program
Importance of Water Quality for Medical Device Reprocessing
Mechanical Cleaning Safety: A Tale of Two Sides
Sterilization Choices for the SPD
When Is Disposable the Right Choice for SPD?
Education Nation: Sterile Processing Leadership Planning Sessions
How Safe Is Your Sink?
Sterile Processing Education – The balancing act between documentation and application
Moisture Absorption Devices….No This Is Not a Wet Pack Article
Positive Biological Indicators
Washer disinfector release for use after maintenance
Beyond the visual: The importance of quality cleaning verification programs
Education nation: Creating Sterile Processing Department SOPs
Cross out cross contamination in endoscope processing
What’s new in AAMI ST79:2017? A review
Healthcare soils 101: Identifying and removing them
Expiration dating in the SPD
The Science of Speed
The fantastic four: Sterile processing, operating room, quality and education
Ugh! Another wet pack. What’s a technician to do?
Sterilization quality control: Validation, routine monitoring go hand in hand
Manual cleaning – The critical human element
Water for cleaning medical devices
Can you afford to ignore obsolescence?
Automatic Equipment and Productivity in a Sterile Processing Department
External Transport of Medical Devices
Troubleshooting Washer-Disinfector Performance

