By Brian Kirk
Creutzfeldt-Jacob Disease (CJD) is one of several transmissible spongiform encephalopathies (TSEs), which are characterized by the accumulation of abnormal forms of the prion protein.1 Clinically, CJD presents as a progressive deterioration of brain function arising from the buildup of misfolded proteins within the brain, which impair normal function, ultimately causing tissue damage. Histological examination indicates the formation of microscopic vacuoles within brain tissue, making it appear sponge-like, hence the use of the term “spongiform”. All known prion diseases are invariably fatal.
Learning Objectives
- Describe routes of prion transmission relevant to sterile service departments.
- Explain the limitations of conventional reprocessing on prions.
- Identify sterile processing practices used to manage potential prion exposure.
- Recognize limitations of sterilization technologies and how monitoring systems affect prion risk management in sterile processing.
About the Author

Dr. Brian Kirk BSc, MSC, PhD, MRPharmS, FIHEEM, AE(D)


